SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells

SopB activates the Akt-YAP pathway to promote Salmonella survival within B cells

B cells are a target of Salmonella infection, allowing bacteria survival without inducing pyroptosis. This event is due to downregulation of Nlrc4 expression and lack of inflammasome complex activation, which impairs the secretion of IL-1β. YAP phosphorylation is required for downregulation of Nlrc4...

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Bibliographic Details
Main Authors: Abraham García-Gil, Carlos Samuel Galán-Enríquez, Araceli Pérez-López, Porfirio Nava, Celia Alpuche-Aranda, Vianney Ortiz-Navarrete
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Salmonella
B cells
SopB
Akt
YAP
IL-1β
Online Access:http://dx.doi.org/10.1080/21505594.2018.1509664

Internet

http://dx.doi.org/10.1080/21505594.2018.1509664

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