Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities

Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities

For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution. Commonly, the performance of a drug formulation is assessed using standardised dissolution apparatus, which does not replicate the hydr...

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Bibliographic Details
Main Authors: Michael Schütt, Konstantinos Stamatopoulos, Hannah K. Batchelor, Mark J. H. Simmons, Alessio Alexiadis
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
mathematical modelling
smoothed particle hydrodynamics (SPH)
fluid dynamics
large intestine
colon
fluid–structure interactions
Online Access:https://www.mdpi.com/1999-4923/13/6/859

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https://www.mdpi.com/1999-4923/13/6/859

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