Evolution of the aging brain transcriptome and synaptic regulation.

Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans. To obtain greater insight into how brain aging has evolved, we compared age-related gene expression changes in the cortex of humans,...

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Bibliographic Details
Main Authors: Patrick M Loerch, Tao Lu, Kelly A Dakin, James M Vann, Adrian Isaacs, Chengiz Geula, Jianbin Wang, Ying Pan, Dana H Gabuzda, Cheng Li, Tomas A Prolla, Bruce A Yankner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2553198?pdf=render