Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists.

Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists.

Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung, b...

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Bibliographic Details
Main Authors: Victoria Vinader, Djevdet S Ahmet, Mohaned S Ahmed, Laurence H Patterson, Kamyar Afarinkia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3800133?pdf=render

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http://europepmc.org/articles/PMC3800133?pdf=render

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