Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs

Improved Cytotoxic T Lymphocyte Responses to Vaccination with Porcine Reproductive and Respiratory Syndrome Virus in 4-1BB Transgenic Pigs

Vaccination is the most reliable measure to prevent infectious diseases in domestic animals. Development of novel vaccines demands extensive studies with new technologies, such as using novel adjuvants and immunomodulatory molecules. The co-stimulatory molecule 4-1BB provides a key signal that direc...

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Bibliographic Details
Main Authors: Guangping Huang, Xianyong Liu, Donal W. Duszynski, Xiaoli Tang, Saeed El-Ashram, Zhengzhu Liu, Xun Suo, Qiuyan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
immune response
viral infection
4-1BB
co-stimulation
transgenic pig
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01846/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01846/full

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