Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway

Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway

Background and Purpose: Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab. Recent studies revealed that osthole, an active coumarin isolated from Cnidium monnieri (L.)...

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Bibliographic Details
Main Authors: Yun Yang, Feng Ren, Ziyin Tian, Wei Song, Binfeng Cheng, Zhiwei Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
trastuzumab
osthole
gastric cancer
apoptosis
AKT
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01392/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01392/full

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