Delayed administration of high dose human immunoglobulin G enhances recovery after traumatic cervical spinal cord injury by modulation of neuroinflammation and protection of the blood spinal cord barrier

Delayed administration of high dose human immunoglobulin G enhances recovery after traumatic cervical spinal cord injury by modulation of neuroinflammation and protection of the blood spinal cord barrier

Background/introduction: The neuroinflammatory response plays a major role in the secondary injury cascade after traumatic spinal cord injury (SCI). To date, systemic anti-inflammatory medications such as methylprednisolone sodium succinate (MPSS) have shown promise in SCI. However, systemic immunos...

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Bibliographic Details
Main Authors: Jonathon Chon Teng Chio, Jian Wang, Vithushan Surendran, Lijun Li, Mohammad-Masoud Zavvarian, Katarzyna Pieczonka, Michael G. Fehlings
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Rat
Spinal cord injury
Human immunoglobulin G
High dose
Neuroinflammation
Immunomodulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304629

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http://www.sciencedirect.com/science/article/pii/S0969996120304629

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