CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs

Abstract Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with cellular and molecular mechanisms yet to be fully described. Mutations in a number of genes including SOD1 and FUS are associated with familial ALS. Here we report the generation of induced pluripotent stem cell...

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Bibliographic Details
Main Authors: Lixia Wang, Fei Yi, Lina Fu, Jiping Yang, Si Wang, Zhaoxia Wang, Keiichiro Suzuki, Liang Sun, Xiuling Xu, Yang Yu, Jie Qiao, Juan Carlos Izpisua Belmonte, Ze Yang, Yun Yuan, Jing Qu, Guang-Hui Liu
Format: Article
Language:English
Published: SpringerOpen 2017-04-01
Series:Protein & Cell
Subjects:
ALS
CRISPR/Cas9
gene correction
iPSC disease modeling
Online Access:http://link.springer.com/article/10.1007/s13238-017-0397-3

Internet

http://link.springer.com/article/10.1007/s13238-017-0397-3

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