Human Recombinant Fab Fragment Neutralizes Shiga Toxin Type 2 Cytotoxic Effects <i>in vitro</i> and <i>in vivo</i>

Human Recombinant Fab Fragment Neutralizes Shiga Toxin Type 2 Cytotoxic Effects <i>in vitro</i> and <i>in vivo</i>

Shiga toxin (Stx) producing <i>Escherichia coli</i> (STEC) is responsible for causing hemolytic uremic syndrome (HUS), a life-threatening thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, and acute renal failure after bacterially induced hemorrhagic diarrhea...

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Bibliographic Details
Main Authors: Daniela Luz, Maria Marta Amaral, Flavia Sacerdoti, Alan Mauro Bernal, Wagner Quintilio, Ana Maria Moro, Marina Sandra Palermo, Cristina Ibarra, Roxane Maria Fontes Piazza
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Toxins
Subjects:
Shiga toxin
recombinant antibody fragment
Fab
neutralization
protection
Online Access:https://www.mdpi.com/2072-6651/10/12/508

Internet

https://www.mdpi.com/2072-6651/10/12/508

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