Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces...

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Bibliographic Details
Main Authors: Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
Class A CpG oligodeoxynucleotide
sepsis
lipopolysaccharide
platelet-activating factor
platelet-activating factor acetylhydrolase
disseminated intravascular coagulation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01049/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01049/full

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