Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells[S]

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells[S]

In specialized cell types, lysosome-related organelles support regulated secretory pathways, whereas in nonspecialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be cont...

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Bibliographic Details
Main Authors: Fabrizio Vacca, Stefania Vossio, Vincent Mercier, Dimitri Moreau, Shem Johnson, Cameron C. Scott, Jonathan Paz Montoya, Marc Moniatte, Jean Gruenberg
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Journal of Lipid Research
Subjects:
cellular cholesterol
cholesterol/trafficking
endocytosis
Niemann-Pick disease
phospholipids/trafficking
lysobisphosphatidic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520325967

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http://www.sciencedirect.com/science/article/pii/S0022227520325967

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