Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells

Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells

Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge <i>Xestospongia</i> sp., with nanomolar IC<sub>50</sub>s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin (DOX) in estrogen receptor...

Full description

Bibliographic Details
Main Authors: Jortan O. Tun, Lilibeth A. Salvador-Reyes, Michael C. Velarde, Naoki Saito, Khanit Suwanborirux, Gisela P. Concepcion
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Marine Drugs
Subjects:
renieramycin M
doxorubicin
synergistic combination chemotherapy
real-time profiling
cell cycle
gene expression profiling
apoptosis
breast cancer
blue sponge
DNA damage response
Online Access:https://www.mdpi.com/1660-3397/17/9/536

Internet

https://www.mdpi.com/1660-3397/17/9/536

Similar Items