CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors

CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors

Cyclin D1 (CCND1) amplification relevant to malignant biological behavior exists in solid tumors. The prevalence and utility of CCND1 amplification as a biomarker for the clinical response to treatment with immune checkpoint inhibitors (ICIs) are unknown. Our study is a preliminary investigation mai...

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Bibliographic Details
Main Authors: Yu Chen, Yingying Huang, Xuan Gao, Yi Li, Jing Lin, Lizhu Chen, Lianpeng Chang, Gang Chen, Yanfang Guan, Leong Kin Pan, Xuefeng Xia, Zengqing Guo, Jianji Pan, Yaping Xu, Xin Yi, Chuanben Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
cyclin D1 (CCND1)
immune checkpoint inhibitors
prognosis
tumor microenvironment
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01620/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01620/full

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