Early Involvement of Death-Associated Protein Kinase Promoter Hypermethylation in the Carcinogenesis of Barrett's Esophageal Adenocarcinoma and Its Association with Clinical Progression

Early Involvement of Death-Associated Protein Kinase Promoter Hypermethylation in the Carcinogenesis of Barrett's Esophageal Adenocarcinoma and Its Association with Clinical Progression

Esophageal Barrett's adenocarcinoma (BA) develops through a multistage process, which is associated with the transcriptional silencing of tumor-suppressor genes by promoter CpG island hypermethylation. In this study, we explored the promoter hypermethylation and protein expression of proapopto...

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Bibliographic Details
Main Authors: Doerthe Kuester, Altaf A. Dar, Christopher C. Moskaluk, Sabine Krueger, Frank Meyer, Roland Hartig, Manfred Stolte, Peter Malfertheiner, Hans Lippert, Albert Roessner, Wael El-Rifai, Regine Schneider-Stock
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Barrett's adenocarcinoma
Barrett's metaplasia
DAPK
reflux esophagitis
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800546

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http://www.sciencedirect.com/science/article/pii/S1476558607800546

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