Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

<p>Abstract</p> <p>Background</p> <p>HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic activity, it necessarily functions through protein-protein interaction interfaces. A critical Nef protein interaction...

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Bibliographic Details
Main Authors: Kuo Lillian S, Baugh Laura L, Denial Sarah J, Watkins Richard L, Liu Mingjie, Garcia J, Foster John L
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Retrovirology
Subjects:
HIV-1
Nef
CD4
MHC class I
p21-activated protein kinase
Protein-protein interaction interface
SH3 domain
Online Access:http://www.retrovirology.com/content/9/1/47

Internet

http://www.retrovirology.com/content/9/1/47

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