Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy

Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy

Abstract Background The functions of HULC have been demonstrated in several cancers. However, its mechanism has not been elucidated in human liver cancer stem cells. Methods Liver cancer stem cells were isolated from Huh7 cells; gene infection and tumorigenesis test in vitro and in vivo were perform...

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Bibliographic Details
Main Authors: Chen Wang, Xiaoxue Jiang, Xiaonan Li, Shuting Song, Qiuyu Meng, Liyan Wang, Yanan Lu, Xiaoru Xin, Hu Pu, Xin Gui, Tianming Li, Dongdong Lu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Stem Cell Research & Therapy
Subjects:
HULC
CyclinD1
miR675
PKM2
Autophagy
Online Access:https://doi.org/10.1186/s13287-019-1528-y

Internet

https://doi.org/10.1186/s13287-019-1528-y

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