Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Platelets support tumor metastasis formation. Here, the authors show that the phosphoinositide signaling modulated by PITPα is essential for platelet-mediated tumor metastasis signaling, but surprisingly it is dispensable in hemostasis in mice.

Bibliographic Details
Main Authors: Liang Zhao, Chelsea L. Thorsheim, Aae Suzuki, Timothy J. Stalker, Sang H. Min, Lurong Lian, Gregory D. Fairn, Shamshad Cockcroft, Amy Durham, Sriram Krishnaswamy, Charles S. Abrams
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01181-4

Internet

https://doi.org/10.1038/s41467-017-01181-4

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