A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation

A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation

Adenosine 5′-monophsphate-activated protein kinase (AMPK) is a crucial energy sensor for maintaining cellular homeostasis. Targeting AMPK may provide an alternative approach in treatment of various diseases like cancer, diabetes, and neurodegenerations. Accordingly, novel AMPK activators are frequen...

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Bibliographic Details
Main Authors: Simon W. F. Mok, Wu Zeng, Yuzhen Niu, Paolo Coghi, Yujun Wu, Wai Man Sin, Sio Ian Ng, Flora Gordillo-Martínez, Jia Yin Gao, Betty Y. K. Law, Liang Liu, Xiaojun Yao, Vincent K. W. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
AMPK
anilides
virtual screening
cytotoxicity
Lipinski’s rule of five
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00710/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00710/full

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