Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11553-7 |