Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

General activation of hypoxia-inducible factor (HIF) pathways is classically associated with adverse prognosis in cancer and has been proposed to contribute to oncogenic drive. In clear cell renal carcinoma (CCRC) HIF pathways are upregulated by inactivation of the von-Hippel-Lindau tumor suppressor...

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Bibliographic Details
Main Authors: Rafik Salama, Norma Masson, Peter Simpson, Lina Katrin Sciesielski, Min Sun, Ya-Min Tian, Peter John Ratcliffe, David Robert Mole
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4532367?pdf=render

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http://europepmc.org/articles/PMC4532367?pdf=render

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