Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization

Blockade of PD-L1 Enhances Cancer Immunotherapy by Regulating Dendritic Cell Maturation and Macrophage Polarization

The immuno-inhibitory checkpoint PD-L1, regulated by tumor cells and antigen-presenting cells (APCs), dampened the activation of T cells from the PD-1/PD-L1 axis. PD-L1-expressing APCs rather than tumor cells demonstrated the essential anti-tumor effects of anti-PD-L1 monotherapy in preclinical tumo...

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Bibliographic Details
Main Authors: Nai-Yun Sun, Yu-Li Chen, Wen-Yih Wu, Han-Wei Lin, Ying-Cheng Chiang, Chi-Fang Chang, Yi-Jou Tai, Heng-Cheng Hsu, Chi-An Chen, Wei-Zen Sun, Wen-Fang Cheng
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
antigen-specific protein vaccine
anti-PD-L1 antibody
antigen-presenting cells
dendritic cells
macrophages
Online Access:https://www.mdpi.com/2072-6694/11/9/1400

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https://www.mdpi.com/2072-6694/11/9/1400

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