Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein

Structural definition of polyspecific compensatory ligand recognition by P-glycoprotein

The multidrug transporter P-glycoprotein (Pgp)/ABCB1/MDR1 plays an important role in multidrug resistance (MDR) and detoxification owing to its ability to efflux an unusually large and chemically diverse set of substrates. Previous phenylalanine-to-alanine scanning mutagenesis of Pgp revealed that n...

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Bibliographic Details
Main Authors: Christina A. Le, Daniel S. Harvey, Stephen G. Aller
Format: Article
Language:English
Published: International Union of Crystallography 2020-07-01
Series:IUCrJ
Subjects:
p-glycoprotein
polyspecificity
crystallography
multidrug resistance
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252520005709

Internet

http://scripts.iucr.org/cgi-bin/paper?S2052252520005709

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