Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

Abstract Background Integrin αvβ3, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis. Recently, we reported that an RGD peptide positron emission tomography (PET) probe is useful as a predictor of hepatic fibrosis....

Full description

Bibliographic Details
Main Authors: Shuichi Hiroyama, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Ippei Morita, Hiroki Maeda, Kae Fujisawa, Keiko Matsunaga, Eku Shimosegawa, Kohji Abe
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:EJNMMI Research
Subjects:
Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic steatohepatitis (NASH)
Fibrosis
Integrin
Arginine–glycine–aspartic acid (RGD)
Positron emission tomography (PET)
Online Access:http://link.springer.com/article/10.1186/s13550-020-00704-3

Internet

http://link.springer.com/article/10.1186/s13550-020-00704-3

Similar Items