BAD and KATP channels regulate neuron excitability and epileptiform activity

BAD and KATP channels regulate neuron excitability and epileptiform activity

Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures; this seizure protection is mediated by ATP-sensi...

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Bibliographic Details
Main Authors: Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
Epilepsy
Calcium imaging
Brain slice
Metabolic seizure resistance
Online Access:https://elifesciences.org/articles/32721

Internet

https://elifesciences.org/articles/32721

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