Sea Cucumber (<i>Stichopus japonicas</i>) F2 Enhanced TRAIL-Induced Apoptosis via XIAP Ubiquitination and ER Stress in Colorectal Cancer Cells

Sea Cucumber (<i>Stichopus japonicas</i>) F2 Enhanced TRAIL-Induced Apoptosis via XIAP Ubiquitination and ER Stress in Colorectal Cancer Cells

Natural products have shown great promise in sensitizing cells to TNF-related apoptosis-inducing ligand (TRAIL) therapy. Sea cucumber (SC) extracts possess antitumor activity, and hence their potential to sensitize colorectal cancer (CRC) cells to TRAIL therapy was evaluated. This study used Western...

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Bibliographic Details
Main Authors: Jung Lim Kim, Seong Hye Park, Soyeon Jeong, Bo Ram Kim, Yoo Jin Na, Min Jee Jo, Yoon A Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bu Gyeom Kim, SangGuan You, Sang Cheul Oh, Dae-Hee Lee
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Nutrients
Subjects:
sea cucumber (SC)
endoplasmic reticulum (ER) stress
X-linked inhibitor of apoptosis protein (XIAP)
c-Jun N-terminal kinase (JNK)
Online Access:https://www.mdpi.com/2072-6643/11/5/1061

Internet

https://www.mdpi.com/2072-6643/11/5/1061

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