SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis

SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis

Bone metastasis is associated with cancer‐related death in patients with prostate cancer (PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa. Nevertheless, the biological function of lncRNAs in PCa bone metastasis remains unclear. PCAT7 was identified as a bone metas...

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Bibliographic Details
Main Authors: Chuandong Lang, Yuhu Dai, Zhengquan Wu, Qing Yang, Shaofu He, Xin Zhang, Wei Guo, Yingrong Lai, Hong Du, Hehe Wang, Dong Ren, Xinsheng Peng
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Oncology
Subjects:
bone metastasis
lncRNA PCAT7
miR‐324‐5p
prostate cancer
TGF‐β signaling
Online Access:https://doi.org/10.1002/1878-0261.12634

Internet

https://doi.org/10.1002/1878-0261.12634

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