Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Abstract Background Ischaemia reperfusion (IR) induces multiple pathophysiological changes. In addition to its classical role in regulating tumourigenesis, the feedback loop formed by p53 and its driven target p53-upregulated modulator of apoptosis (PUMA) was recently demonstrated to be the common n...

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Bibliographic Details
Main Authors: Xiao-Qian Li, Qian Yu, Feng-Shou Chen, Wen-Fei Tan, Zai-Li Zhang, Hong Ma
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Apoptosis
Blood-spinal cord barrier
Inflammation
Ischaemia reperfusion
p53
p53 upregulated modulator of apoptosis
Online Access:http://link.springer.com/article/10.1186/s12974-018-1271-9

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http://link.springer.com/article/10.1186/s12974-018-1271-9

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