Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent.
Targeting transgenes to a chosen location in the genome has a number of advantages. A single copy of the DNA construct can be inserted by targeting into regions of chromatin that allow the desired developmental and tissue-specific expression of the transgene.In order to develop a reliable system for...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-12-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC1762389?pdf=render |