Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington's disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD pathogenesis is unknown. We examined the role...

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Bibliographic Details
Main Authors: Eduardo E. Arteaga-Bracho, Maria Gulinello, Michael L. Winchester, Nandini Pichamoorthy, Jenna R. Petronglo, Alicia D. Zambrano, Julio Inocencio, Chirstopher D. De Jesus, Joseph O. Louie, Solen Gokhan, Mark F. Mehler, Aldrin E. Molero
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Huntingtin
Development
Degeneration
Pathogenesis
Neurogenesis
Gliogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630225X

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http://www.sciencedirect.com/science/article/pii/S096999611630225X

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