Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase

Increased pain and neurogenic inflammation in mice deficient of neutral endopeptidase

The complex regional pain syndrome (CRPS) is characterized by enhanced neurogenic inflammation, mediated by neuropeptides. Neutral endopeptidase (NEP) is a key enzyme in neuropeptide catabolism. We used NEP knock out (ko) mice to investigate whether NEP deficiency leads to increased pain behavior an...

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Bibliographic Details
Main Authors: Heidrun H. Krämer, Lan He, Bao Lu, Frank Birklein, Claudia Sommer
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
CGRP catabolism
Neutral endopeptidase
CCI
Primarily cold CRPS
Endothelin 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002805

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http://www.sciencedirect.com/science/article/pii/S0969996108002805

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