Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology

Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology

Lipotoxic cardiomyopathy (LCM) is characterized by cardiac steatosis, including the accumulation of fatty acids, triglycerides and ceramides. Model systems have shown the inhibition of ceramide biosynthesis to antagonize obesity and improve insulin sensitivity. Sphingosine Δ4 desaturase (encoded by...

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Bibliographic Details
Main Authors: Stanley M. Walls, Dale A. Chatfield, Karen Ocorr, Greg L. Harris, Rolf Bodmer
Format: Article
Language:English
Published: The Company of Biologists 2020-08-01
Series:Disease Models & Mechanisms
Subjects:
ifc
sphingosine δ4 desaturase
dihydroceramide
sphingolipid metabolism
ceramide
cardiac
Online Access:http://dmm.biologists.org/content/13/8/dmm043083

Internet

http://dmm.biologists.org/content/13/8/dmm043083

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