Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Exploiting genetic variation to uncover rules of transcription factor binding and chromatin accessibility

Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin occupancy and chromatin accessibility.

Bibliographic Details
Main Authors: Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03082-6

Internet

https://doi.org/10.1038/s41467-018-03082-6

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