Candidate Tumor-Suppressor Gene DLEC1 Is Frequently Downregulated by Promoter Hypermethylation and Histone Hypoacetylation in Human Epithelial Ovarian Cancer

Candidate Tumor-Suppressor Gene DLEC1 Is Frequently Downregulated by Promoter Hypermethylation and Histone Hypoacetylation in Human Epithelial Ovarian Cancer

Suppression of ovarian tumor growth by chromosome 3p was demonstrated in a previous study. Deleted in Lung and Esophageal Cancer 1 (DLEC1) on 3p22.3 is a candidate tumor suppressor in lung, esophageal, and renal cancers. The potential involvement of DLEC1 in epithelial ovarian cancer remains unknow...

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Bibliographic Details
Main Authors: Joseph Kwong, Ji-Young Lee, Kwong-Kwok Wong, Xiaofeng Zhou, David T.W. Wong, Kwok-Wai Lo, William R. Welch, Ross S. Berkowitz, Samuel C. Mok
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
DLEC1
chromosome 3p22.3
promoter hypermethylation
histone hypoacetylation
epithelial ovarian cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800667

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http://www.sciencedirect.com/science/article/pii/S1476558606800667

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