A prospective study to assess the association between genotype, phenotype and Prakriti in individuals on phenytoin monotherapy

Background: Genetic polymorphisms in drug metabolizing enzymes (DMEs) impart distinct drug metabolizing capacity and a unique phenotype to an individual. Phenytoin has large inter-individual variability in metabolism due to polymorphisms in CYP2C9 and CYP2C19. As per Ayurveda, Prakriti imparts a uni...

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Bibliographic Details
Main Authors: Saket J. Thaker, Prajakta P. Gandhe, Charuta J. Godbole, Shital R. Bendkhale, Nitin B. Mali, Urmila M. Thatte, Nithya J. Gogtay
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Ayurveda and Integrative Medicine
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0975947616303527