Identification of new allosteric sites and modulators of AChE through computational and experimental tools

Identification of new allosteric sites and modulators of AChE through computational and experimental tools

Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for am...

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Bibliographic Details
Main Authors: Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L. Blundell, Nuria E. Campillo
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
AChE
allosteric sites
Alzheimer diseases
molecular dynamics
allosteric inhibitors
Online Access:http://dx.doi.org/10.1080/14756366.2018.1476502

Internet

http://dx.doi.org/10.1080/14756366.2018.1476502

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