In vivo tau pathology is associated with synaptic loss and altered synaptic function

In vivo tau pathology is associated with synaptic loss and altered synaptic function

Abstract Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau patho...

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Bibliographic Details
Main Authors: Emma M. Coomans, Deborah N. Schoonhoven, Hayel Tuncel, Sander C. J. Verfaillie, Emma E. Wolters, Ronald Boellaard, Rik Ossenkoppele, Anouk den Braber, Wiep Scheper, Patrick Schober, Steven P. Sweeney, J. Michael Ryan, Robert C. Schuit, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Sandeep S. V. Golla, Arjan Hillebrand, Alida A. Gouw, Bart N. M. van Berckel
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer
Tau
Synaptic density
Synaptic function
PET
MEG
Online Access:https://doi.org/10.1186/s13195-021-00772-0

Internet

https://doi.org/10.1186/s13195-021-00772-0

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