Experimental and Computational Studies Unraveling the Peculiarity of Enolizable Oxoesters in the Organocatalyzed Mannich-Type Addition to Cyclic <i>N</i>-Acyl Iminium Ions

Experimental and Computational Studies Unraveling the Peculiarity of Enolizable Oxoesters in the Organocatalyzed Mannich-Type Addition to Cyclic <i>N</i>-Acyl Iminium Ions

 and δ-Oxoesters are easily available starting materials that have been sparingly used in some organocatalyzed reactions proceeding with a high enantioselectivity. In our experimentation we found that the use of these compounds as the enolizable (nucleophilic) component in organocatalyzed Mannich-...

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Bibliographic Details
Main Authors: Andrea Menichetti, Sebastiano Di Pietro, Valeria Di Bussolo, Lucilla Favero, Mauro Pineschi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
N,O-acetals
organocatalysis
oxoesters
Mannich reactions
DFT study
heteroaryl lactones
Online Access:https://www.mdpi.com/1420-3049/25/8/1903

Internet

https://www.mdpi.com/1420-3049/25/8/1903

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