Identifying genomic targets for protein over-expression by “omics” analysis of Quiescent Escherichia coli cultures
Abstract Background A cellular stress response is triggered upon induction of recombinant protein expression which feedback inhibits both growth as well as protein synthesis. In order to separate these two effects, it was decided to study “quiescent cultures” which continue to be metabolically activ...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-07-01
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Series: | Microbial Cell Factories |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12934-017-0744-3 |