Transcriptional drug repositioning and cheminformatics approach for differentiation therapy of leukaemia cells

Abstract Differentiation therapy is attracting increasing interest in cancer as it can be more specific than conventional chemotherapy approaches, and it has offered new treatment options for some cancer types, such as treating acute promyelocytic leukaemia (APL) by retinoic acid. However, there is...

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Bibliographic Details
Main Authors: Yasaman KalantarMotamedi, Fatemeh Ejeian, Faezeh Sabouhi, Leila Bahmani, Alireza Shoaraye Nejati, Aditya Mukund Bhagwat, Ali Mohammad Ahadi, Azita Parvaneh Tafreshi, Mohammad Hossein Nasr-Esfahani, Andreas Bender
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91629-x