PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation

PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation

Summary: Peroxisome-proliferator-activated receptor γ (PPARγ) regulates glucose and lipid homeostasis, insulin signaling, and adipocyte differentiation. Here, we report the skipping of exon 5 as a legitimate splicing event generating PPARγΔ5, a previously unidentified naturally occurring truncated i...

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Bibliographic Details
Main Authors: Marianna Aprile, Simona Cataldi, Maria Rosaria Ambrosio, Vittoria D’Esposito, Koini Lim, Arne Dietrich, Matthias Blüher, David Bousfield Savage, Pietro Formisano, Alfredo Ciccodicola, Valerio Costa
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316115

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http://www.sciencedirect.com/science/article/pii/S2211124718316115

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