Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity

Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity

Genome rearrangements, a hallmark of cancer, can result in gene fusions with oncogenic properties. Using DNA paired-end-tag (DNA-PET) whole-genome sequencing, we analyzed 15 gastric cancers (GCs) from Southeast Asians. Rearrangements were enriched in open chromatin and shaped by chromatin structure....

Full description

Bibliographic Details
Main Authors: Fei Yao, Jaya P. Kausalya, Yee Yen Sia, Audrey S.M. Teo, Wah Heng Lee, Alicia G.M. Ong, Zhenshui Zhang, Joanna H.J. Tan, Guoliang Li, Denis Bertrand, Xingliang Liu, Huay Mei Poh, Peiyong Guan, Feng Zhu, Thushangi Nadeera Pathiraja, Pramila N. Ariyaratne, Jaideepraj Rao, Xing Yi Woo, Shaojiang Cai, Fabianus H. Mulawadi, Wan Ting Poh, Lavanya Veeravalli, Chee Seng Chan, Seong Soo Lim, See Ting Leong, Say Chuan Neo, Poh Sum D. Choi, Elaine G.Y. Chew, Niranjan Nagarajan, Pierre-Étienne Jacques, Jimmy B.Y. So, Xiaoan Ruan, Khay Guan Yeoh, Patrick Tan, Wing-Kin Sung, Walter Hunziker, Yijun Ruan, Axel M. Hillmer
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471500618X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471500618X

Similar Items