Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest

Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest

Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary blood flow rapidly leads to intense myocardial ischemia and activation of the sarcolemmal Na<sup>+</sup>-H<sup>+</sup> e...

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Bibliographic Details
Main Authors: Raúl J. Gazmuri, Jeejabai Radhakrishnan, Iyad M. Ayoub
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Molecules
Subjects:
cardiopulmonary resuscitation
energy metabolism
ischemia
mitochondria
myocardium
reperfusion injury
sodium calcium exchanger
sudden cardiac arrest
ventricular function
Online Access:https://www.mdpi.com/1420-3049/24/9/1765

Internet

https://www.mdpi.com/1420-3049/24/9/1765

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