CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

Abstract Background The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms. Several recent studies have reported that such mutants can lead to in-frame exon skipping in cell lines. However, there was little rese...

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Bibliographic Details
Main Authors: Dafeng Chen, Ji-Xin Tang, Beibei Li, Li Hou, Xianhui Wang, Le Kang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Biotechnology
Subjects:
CRISPR/Cas9
Gene editing
Exon skipping
Migratory locust
Pre-mRNA splicing
Online Access:http://link.springer.com/article/10.1186/s12896-018-0465-7

Internet

http://link.springer.com/article/10.1186/s12896-018-0465-7

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