Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch

Male factor infertility is a problem in today’s society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model. Expression of the gap junction protein Cx43...

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Bibliographic Details
Main Authors: Erika Hilbold, Ottmar Distl, Martina Hoedemaker, Sandra Wilkening, Rüdiger Behr, Aleksandar Rajkovic, Marion Langeheine, Kristina Rode, Klaus Jung, Julia Metzger, Ralph H. J. Brehm
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
cx43
impaired spermatogenesis
mitosis-meiosis switch
sertoli cell maturation
ngs
Online Access:https://www.mdpi.com/2073-4409/9/3/676

Internet

https://www.mdpi.com/2073-4409/9/3/676

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