Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

Abstract Background Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) can modulate cell behavior, the contributi...

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Bibliographic Details
Main Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen, Mingli Han
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Molecular Cancer
Subjects:
Breast cancer
Trastuzumab
TINCR
miR-125b
HER-2
Snail-1
Online Access:http://link.springer.com/article/10.1186/s12943-018-0931-9

Internet

http://link.springer.com/article/10.1186/s12943-018-0931-9

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