Streptococcal M1 protein induces hyporesponsiveness and cytokine release from human arteries in a fibrinogen-dependent manner: a translational study

Streptococcal M1 protein induces hyporesponsiveness and cytokine release from human arteries in a fibrinogen-dependent manner: a translational study

Abstract Background Streptococcus pyogenes is a Gram positive bacterial species commonly involved in sepsis. Invasive strains express virulence factors such as the M1 protein. M1 protein forms complexes with fibrinogen leading to a cytokine storm in plasma contributing to the development of septic s...

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Bibliographic Details
Main Authors: Viveka Björck, Lisa I. Påhlman, Johan Törnebrant, Mikael Bodelsson
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Subjects:
Sepsis
M1 protein
Hypotension
Cytokine
Interleukin
Fibrinogen
Online Access:http://link.springer.com/article/10.1186/s13049-018-0530-1

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http://link.springer.com/article/10.1186/s13049-018-0530-1

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