Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Further...

Full description

Bibliographic Details
Main Authors: Erika Casari, Carlo Rinaldi, Antonio Marsella, Marco Gnugnoli, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
Mre11
Rad50
Xrs2/NBS1
Sae2/CtIP
Tel1/ATM
MRX complex
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00043/full
id doaj-02857ddb75954b589733cfeba7178062
record_format Article
spelling doaj-02857ddb75954b589733cfeba71780622020-11-25T01:02:08ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2019-06-01610.3389/fmolb.2019.00043461573Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin ContextErika CasariCarlo RinaldiAntonio MarsellaMarco GnugnoliChiara Vittoria ColomboDiego BonettiMaria Pia LongheseDNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Furthermore, it is responsible for DSB signaling through the activation of the checkpoint kinase Tel1/ATM. Here, we review functions and regulation of the MRX/MRN complex in DSB processing in a chromatin context, as well as its interplay with Tel1/ATM.https://www.frontiersin.org/article/10.3389/fmolb.2019.00043/fullMre11Rad50Xrs2/NBS1Sae2/CtIPTel1/ATMMRX complex
collection DOAJ
language English
format Article
sources DOAJ
author Erika Casari
Carlo Rinaldi
Antonio Marsella
Marco Gnugnoli
Chiara Vittoria Colombo
Diego Bonetti
Maria Pia Longhese
spellingShingle Erika Casari
Carlo Rinaldi
Antonio Marsella
Marco Gnugnoli
Chiara Vittoria Colombo
Diego Bonetti
Maria Pia Longhese
Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
Frontiers in Molecular Biosciences
Mre11
Rad50
Xrs2/NBS1
Sae2/CtIP
Tel1/ATM
MRX complex
author_facet Erika Casari
Carlo Rinaldi
Antonio Marsella
Marco Gnugnoli
Chiara Vittoria Colombo
Diego Bonetti
Maria Pia Longhese
author_sort Erika Casari
title Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
title_short Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
title_full Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
title_fullStr Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
title_full_unstemmed Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context
title_sort processing of dna double-strand breaks by the mrx complex in a chromatin context
publisher Frontiers Media S.A.
series Frontiers in Molecular Biosciences
issn 2296-889X
publishDate 2019-06-01
description DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Furthermore, it is responsible for DSB signaling through the activation of the checkpoint kinase Tel1/ATM. Here, we review functions and regulation of the MRX/MRN complex in DSB processing in a chromatin context, as well as its interplay with Tel1/ATM.
topic Mre11
Rad50
Xrs2/NBS1
Sae2/CtIP
Tel1/ATM
MRX complex
url https://www.frontiersin.org/article/10.3389/fmolb.2019.00043/full
work_keys_str_mv AT erikacasari processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT carlorinaldi processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT antoniomarsella processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT marcognugnoli processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT chiaravittoriacolombo processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT diegobonetti processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
AT mariapialonghese processingofdnadoublestrandbreaksbythemrxcomplexinachromatincontext
_version_ 1725206512073179136

Similar Items