Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Further...

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Bibliographic Details
Main Authors: Erika Casari, Carlo Rinaldi, Antonio Marsella, Marco Gnugnoli, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
Mre11
Rad50
Xrs2/NBS1
Sae2/CtIP
Tel1/ATM
MRX complex
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00043/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00043/full

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