Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance

Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance

Abstract Genome-scale CRISPR-Cas9 Knockout Screening was applied to investigate novel targets in imatinib-resistant gastrointestinal stromal tumor (GIST). 20 genes and 2 miRNAs have been selected by total reads of sgRNA and sgRNA diversity, which has been further validated in imatinib-resistant GIST...

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Bibliographic Details
Main Authors: Jie Cao, Jianchang Wei, Ping Yang, Tong Zhang, Zhuanpeng Chen, Feng He, Fang Wei, Huacui Chen, He Hu, Junbin Zhong, Zhi Yang, Wensong Cai, Wanglin Li, Qiang Wang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
Gastrointestinal stromal tumor
Imatinib resistance
Genome-scale CRISPR-Cas9 knockout screening
Online Access:http://link.springer.com/article/10.1186/s12943-018-0865-2

Internet

http://link.springer.com/article/10.1186/s12943-018-0865-2

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