HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice.

HET0016, a selective inhibitor of 20-HETE synthesis, decreases pro-angiogenic factors and inhibits growth of triple negative breast cancer in mice.

A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-23...

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Bibliographic Details
Main Authors: Thaiz Ferraz Borin, Debora A P C Zuccari, Bruna V Jardim-Perassi, Lívia C Ferreira, A S M Iskander, Nadimpalli Ravi S Varma, Adarsh Shankar, Austin M Guo, Guillermo Scicli, Ali S Arbab
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4280215?pdf=render

Internet

http://europepmc.org/articles/PMC4280215?pdf=render

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